Lithium Hydroxide → HCID 69890113, compound

HRID 1634310Notes

Reaction equation

HRID 1634310 reaction equation
C1(S([N:10]2[C:18]3[C:13](=[CH:14][C:15]([Cl:19])=[CH:16][CH:17]=3)[C:12]([C:20](=[O:34])[CH:21]=[C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([O:32]C)=[O:31])[CH:25]=3)[OH:23])=[CH:11]2)(=O)=O)C=CC=CC=1.[OH-].[Li+]>CO>[Cl:19][C:15]1[CH:14]=[C:13]2[C:18](=[CH:17][CH:16]=1)[NH:10][CH:11]=[C:12]2[C:20](=[O:34])[CH:21]=[C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([OH:32])=[O:31])[CH:25]=1)[OH:23]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 69892220HCID 69892220, compound

Product 1

HCID 69890113HCID 69890113, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The carboxylic acid in Example 100 was esterified to 1-(1-benzenesulfonyl-5-chloroindol-3-yl)-3-(3-methoxycarbonylphenyl)-3-hydroxy-propen-1-one. The compound was hydrolyzed with lithium hydroxide in methanol to give the tiled compound.

Workup

  1. customto give the tiled compound

Sources & evidence

ORD record
ord-6b200cbee3d243eca2104f48fe53fbac
Source dataset
uspto-grants-2003_01
Patent number
US06506787B2

Reaction notes

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