Tert-butyl 3-amino-2-phenylpiperidine-1-carboxylate → (2S,3S)-1-tert-Butoxycarbonyl-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino2-phenylpiperidine

HRID 1634337Notes

Reaction equation

HRID 1634337 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH:3]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH3:21][O:22][C:23]1[CH:30]=[CH:29][C:28]([C:31]([F:37])([F:36])[C:32]([F:35])([F:34])[F:33])=[CH:27][C:24]=1[CH:25]=O.C(OC(N1CCC[C@H](NCC2C=C(C(F)(F)C)C=CC=2OC(F)(F)F)[C@@H]1C1C=CC=CC=1)=O)(C)(C)C>>[C:11]([O:10][C:8]([N:4]1[CH2:5][CH2:6][CH2:7][C@H:2]([NH:1][CH2:25][C:24]2[CH:27]=[C:28]([C:31]([F:36])([F:37])[C:32]([F:33])([F:34])[F:35])[CH:29]=[CH:30][C:23]=2[O:22][CH3:21])[C@@H:3]1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:9])([CH3:14])([CH3:13])[CH3:12]

Participants

4

Reactant 3

HCID 10214733Tert-butyl 3-amino-2-phenylpiperidine-1-carboxylateHCID 186776122-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzaldehydeHCID 70001814HCID 70001814, compound

Product 1

HCID 86757655(2S,3S)-1-tert-Butoxycarbonyl-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino2-phenylpiperidine

Procedure

This Compound was prepared from Compound 12 and Compound 40 in the same manner of Compound 26. This was employed in the next step without further purification.

Workup

  1. customThis was employed in the next step without further purification

Sources & evidence

ORD record
ord-52a65bf15e6d490e9911b3627ff58b04
Source dataset
uspto-grants-2003_01
Patent number
US06506775B1

Reaction notes

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