(2S,3S)-3-[5-(1,1-Dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochloride → (2S,3S)-2-Phenyl-3-(5-(2,2,2-trifluoro-1-methyl-1-(trifluoromethyl)ethyl)-2-methoxybenzyl)aminopiperidine dihydrochloride
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([NH:14][CH2:15][C:16]2[CH:21]=[C:20]([C:22]([CH3:31])([C:27]([F:30])([F:29])[F:28])[C:23]([F:26])([F:25])[F:24])[CH:19]=[CH:18][C:17]=2[O:32][CH3:33])[C@@H:9]1[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=O)(C)(C)C.[ClH:40].Cl.CC(C1C=CC(OC)=C(C=1)CN[C@H]1CCCN[C@H]1C1C=CC=CC=1)(C)C#CC(F)(F)F>>[ClH:40].[ClH:40].[C:34]1([C@H:9]2[C@@H:10]([NH:14][CH2:15][C:16]3[CH:21]=[C:20]([C:22]([CH3:31])([C:27]([F:28])([F:29])[F:30])[C:23]([F:24])([F:25])[F:26])[CH:19]=[CH:18][C:17]=3[O:32][CH3:33])[CH2:11][CH2:12][CH2:13][NH:8]2)[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1Participants
3
Reactant 2
Product 1
Procedure
This compound was prepared from Compound 77 in the same manner of Compound 60.
Sources & evidence
- ORD record
- ord-8774bd3a3137460783535bd1a1be4f2d
- Source dataset
- uspto-grants-2003_01
- Patent number
- US06506775B1
Reaction notes
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