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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1634354Generated: November 3, 2026

(2S,3S)-3-[5-(1,1-Dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochloride → (2S,3S)-2-Phenyl-3-(5-(2,2,2-trifluoro-1-methyl-1-(trifluoromethyl)ethyl)-2-methoxybenzyl)aminopiperidine dihydrochloride

https://huagongshe.com/reaction/1634354

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S,3S)-3-[5-(1,1-Dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochlorideHCID 70000615—
Reactant(2S,3S)-1-tert-Butoxycarbonyl-2-phenyl-3-(5-(2,2,2-trifluoro-1-methyl-1-(trifluoromethyl)ethyl)-2-methoxybenzyl)aminopiperidineHCID 86758792—
Product(2S,3S)-2-Phenyl-3-(5-(2,2,2-trifluoro-1-methyl-1-(trifluoromethyl)ethyl)-2-methoxybenzyl)aminopiperidine dihydrochlorideHCID 86758791—

Reaction Steps

This compound was prepared from Compound 77 in the same manner of Compound 60.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06506775B1
Source datasetuspto-grants-2003_01
ORD IDord-8774bd3a3137460783535bd1a1be4f2d
Source noteuspto-grants-2003_01