Tert-butyl 3-amino-2-phenylpiperidine-1-carboxylate → (2S,3S)-1-tert-Butoxycarbonyl-3-[5-[2,2-difluoro-1-(trifluoromethyl)ethenyl]-2-methoxybenzyl]amino-2-phenylpiperidine

HRID 1634356Notes

Reaction equation

HRID 1634356 reaction equation
[F:1][C:2]([F:18])=[C:3]([C:8]1[CH:9]=[CH:10][C:11]([O:16][CH3:17])=[C:12]([CH:15]=1)[CH:13]=O)[C:4]([F:7])([F:6])[F:5].[NH2:19][CH:20]1[CH2:25][CH2:24][CH2:23][N:22]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH:21]1[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[C:29]([O:28][C:26]([N:22]1[CH2:23][CH2:24][CH2:25][C@H:20]([NH:19][CH2:13][C:12]2[CH:15]=[C:8]([C:3]([C:4]([F:7])([F:6])[F:5])=[C:2]([F:18])[F:1])[CH:9]=[CH:10][C:11]=2[O:16][CH3:17])[C@@H:21]1[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:27])([CH3:32])([CH3:30])[CH3:31]

Participants

3

Reactant 2

HCID 10214733Tert-butyl 3-amino-2-phenylpiperidine-1-carboxylateHCID 186775965-[2,2-Difluoro-1-(trifluoromethyl)ethenyl]-2-methoxybenzaldehyde

Product 1

HCID 70001040(2S,3S)-1-tert-Butoxycarbonyl-3-[5-[2,2-difluoro-1-(trifluoromethyl)ethenyl]-2-methoxybenzyl]amino-2-phenylpiperidine

Procedure

This compound was prepared from Compound 79 and Compound 12 in the same manner of Compound 13.

Sources & evidence

ORD record
ord-7cb25ba7ccca4541af0ceee5f425c219
Source dataset
uspto-grants-2003_01
Patent number
US06506775B1

Reaction notes

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