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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1634356Generated: October 26, 2026

Tert-butyl 3-amino-2-phenylpiperidine-1-carboxylate → (2S,3S)-1-tert-Butoxycarbonyl-3-[5-[2,2-difluoro-1-(trifluoromethyl)ethenyl]-2-methoxybenzyl]amino-2-phenylpiperidine

https://huagongshe.com/reaction/1634356

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-butyl 3-amino-2-phenylpiperidine-1-carboxylateHCID 10214733—
Reactant5-[2,2-Difluoro-1-(trifluoromethyl)ethenyl]-2-methoxybenzaldehydeHCID 18677596—
Product(2S,3S)-1-tert-Butoxycarbonyl-3-[5-[2,2-difluoro-1-(trifluoromethyl)ethenyl]-2-methoxybenzyl]amino-2-phenylpiperidineHCID 70001040—

Reaction Steps

This compound was prepared from Compound 79 and Compound 12 in the same manner of Compound 13.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06506775B1
Source datasetuspto-grants-2003_01
ORD IDord-7cb25ba7ccca4541af0ceee5f425c219
Source noteuspto-grants-2003_01