反应详情

Treat a solution of N-(2-amino-ethyl)-2-(4-ethoxy-3-methoxy-phenyl)acetamide (0.7 g, 2.77 mmol) in THF (10 mL) with AlH3.NMe2Et (55 mL, 27.74 mmol) and heat to reflux for 14 h. Cool the resulting mixture to ambient temperature, quench with Na2CO3.10H2O (0.5 g) and stir at ambient temperature for 15 min. Filter the solution through Celite and wash with several portions of CH2Cl2. Concentrate the filtrate in vacuoo and purify by preparative TLC (10% MeOH in CH2Cl2) to obtain the title compound as a white oil.

1. temperatureto reflux for 14 h
2. customquench with Na2CO3.10H2O (0.5 g)
3. filtrationFilter the solution through Celite
4. washwash with several portions of CH2Cl2
5. concentrationConcentrate the filtrate in vacuoo
6. custompurify by preparative TLC (10% MeOH in CH2Cl2)