反应详情

Treat a solution of N-[5-methyl-3-(2,4,6-trimethylphenyl)imidazolo[5,4-b]pyridin-7-yl]-2-chloroacetamide (0.04 g, 0.10 mmol) in THF (5 mL) with borane-methyl sulfide complex (0.03 mL, 0.30 mmol). Heat the mixture to reflux for 8 h and quench at ambient temperature with a large excess of MeOH), followed by 6N HCl (2 mL). Re-heat the mixture to reflux for 1 h, then concentrate under reduced pressure to obtain the title compound as a yellow solid.

1. temperatureHeat the mixture
2. temperatureto reflux for 8 h
3. customquench at ambient temperature with a large excess of MeOH),
4. temperatureRe-heat the mixture to reflux for 1 h
5. concentrationconcentrate under reduced pressure