反应详情

A solution of 4-[(2S)-oxiranylmethoxy]-9H-carbazole (0.183 g, 0.76 mmol) in 20 mL dry methylene chloride was treated with 0.258 g of 56-86% m-chloroperbenzoic acid. The reaction was stirred at ambient temperature for 45 minutes. The reaction mixture was partitioned with saturated sodium bicarbonate (sat'd NaHCO3) The organic phase was dried (Na2SO4) and concentrated to a dark red oil. Purification by flash chromatography eluting with methylene chloride (CH2Cl2), afforded 0.040 g of the title compound.

1. customThe reaction mixture was partitioned with saturated sodium bicarbonate (sat'd NaHCO3) The organic phase
2. dry with materialwas dried (Na2SO4)
3. concentrationconcentrated to a dark red oil
4. customPurification by flash chromatography
5. washeluting with methylene chloride (CH2Cl2)