反应详情

4-{[t -Butyl(diphenyl)silyl]oxy}-3-fluorophenyl acetate (5.28 g, 12.92 mmol) was dissolved in methanol (100 mL). 1N NaOH (15.5 mL) was added. The solution was stirred for 30 minutes at ambient temperature. 1N HCl (16 mL) was added. The solvent was removed in vacuo and the solid partitioned between dichloromethane and water. The aqueous phase was washed with dichloromethane. The organic layers were combined and the solvent dried over anhydrous magnesium sulfate. The solution was filtered and the solvent evaporated to dryness in vacuo to yield crude title compound (4.5 g, 12.28 mmol).

1. customThe solvent was removed in vacuo
2. customthe solid partitioned between dichloromethane and water
3. washThe aqueous phase was washed with dichloromethane
4. dry with materialthe solvent dried over anhydrous magnesium sulfate
5. filtrationThe solution was filtered
6. customthe solvent evaporated to dryness in vacuo