4-Piperidinecarboxamide → 1-Isopropylpiperidine-4-carboxamide

HRID 1634749Notes

Reaction equation

[NH:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1.I[CH:11]([CH3:13])[CH3:12].C(=O)([O-])[O-].[K+].[K+]>>[CH:11]([N:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1)([CH3:13])[CH3:12]

Participants

Reactant 3

HCID 37724-Piperidinecarboxamide

HCID 6362Isopropyl iodide

HCID 11430Potassium Carbonate

Product 1

HCID 223944381-Isopropylpiperidine-4-carboxamideYield 94.1%

Procedure

Prepared from isonipecotamide (2.0 g, 15.6 mmol), 2-iodopropane (3.10 mL, 31.2 mmol) of potassium carbonate and (2.15 g, 5.6 mmol) according to the procedure used for Example 8 (Step A) to give 2.5 g of the title compound.

Sources & evidence

ORD record: ord-09d3dc8f76eb4ca6bb65d6082c54ca41
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06506901B2

Reaction notes

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