HCID 18678470, compound → HCID 18678579, compound

HRID 1634753Notes

Reaction equation

HRID 1634753 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([C:11]([NH2:13])=O)[CH2:7][CH2:6]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[NH2:13][CH2:11][CH:8]1[CH2:9][CH2:10][N:5]([CH2:4][CH2:3][C:2]([F:15])([F:1])[F:14])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 18678470HCID 18678470, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 18678579HCID 18678579, compoundYield 96%

Procedure

Prepared from 1-(3,3,3-trifluoropropyl)-piperidine-4-carboxamide (1.0 g, 4.46 mmol) and LAH (0.34 g, 8.9 mmol) according to general the procedure used for Example 8 (Step B) to give 0.9 g of title compound as a white solid.

Sources & evidence

ORD record
ord-230499c4f2c745a191b79e928228ff2e
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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