反应详情

A solution of 4-(2-hydroxy-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propoxy)-fluoren-9-one (0.060 g, 0.13 mmol) in 4 mL THF was treated with LAH (0.010 g, 0.26 mmol) and stirred at ambient temperature overnight. Heated to reflux and cooled. The excess LAH was decomposed by the sequential addition of 0.01 mL of each of water and 1 N NaOH, 0.03 mL of water and 0.5 g Na2SO4. The solids were filtered and the filtrate concentrated in vacuo to give 0.045 g of the title compound as a yellow solid.

1. temperatureHeated
2. temperatureto reflux
3. temperaturecooled
4. filtrationThe solids were filtered
5. concentrationthe filtrate concentrated in vacuo