HCID 18678407, compound → HCID 18678636, compound

HRID 1634767Notes

Reaction equation

HRID 1634767 reaction equation
[F:1][C:2]([F:16])([F:15])[CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([C:12]([NH2:14])=O)[CH2:8][CH2:7]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[NH2:14][CH2:12][CH:9]1[CH2:10][CH2:11][N:6]([CH2:5][CH2:4][CH2:3][C:2]([F:16])([F:1])[F:15])[CH2:7][CH2:8]1

Participants

3

Reactant 2

HCID 18678407HCID 18678407, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 18678636HCID 18678636, compoundYield 98.6%

Procedure

Prepared from 1-(4,4,4-trifluorobutyl)-piperidine-4-carboxamide (0.82 g, 3.3 mmol) and LAH (0.25 g, 6.6 mmol) according to general the procedure used for Example 8 (Step B) to give 0.73 g of title compound as a clear oil.

Sources & evidence

ORD record
ord-038861febb4446bdac6f449ad42c735a
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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