4-Piperidinecarboxamide → HCID 4184048, compound

HRID 1634769Notes

Reaction equation

[NH:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1.I[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].C(=O)([O-])[O-].[K+].[K+]>>[CH2:11]([N:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1)[CH2:12][CH2:13][CH2:14][CH3:15]

Participants

Reactant 3

HCID 37724-Piperidinecarboxamide

HCID 11430Potassium Carbonate

HCID 123351-Iodopentane

Product 1

HCID 4184048HCID 4184048, compoundYield 59.8%

Procedure

Prepared from isonipecotamide (3.3, 25.7 mmol), 1-iodopentane (5.1 g, 25.7 mmol) and potassium carbonate (3.54 g, 25.7 mmol) according to the procedure used for Example 8 (Step A) to give 3.05 g of the title compound as an off-white solid.

Sources & evidence

ORD record: ord-a4b68a7a841e47b88e9d9e017b68426c
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06506901B2

Reaction notes

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