4-Piperidinecarboxamide → HCID 18678406, compound

HRID 1634775Notes

Reaction equation

HRID 1634775 reaction equation
[NH:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1.I[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].C(=O)([O-])[O-].[K+].[K+]>>[CH2:11]([N:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

4

Reactant 3

HCID 37724-PiperidinecarboxamideHCID 11430Potassium CarbonateHCID 123801-Iodooctane

Product 1

HCID 18678406HCID 18678406, compoundYield 110.9%

Procedure

Prepared from isonipecotamide (2.7 g, 21.0 mmol), 1-iodooctane (5.05 g, 21.0 mmol) and potassium carbonate (2.9 g, 21.0 mmol) of according to procedure used for Example 8 (Step A) to give 5.6 g of the title compound as a white solid.

Sources & evidence

ORD record
ord-1a62d424261446a1bef33bd8df9a80e5
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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