HCID 18678703, compound → (2S)-1-(3-Bromo-9H-carbazol-4-yloxy)-3-{[1-(4-methoxy-benzenesulfonyl)-piperidin-4-ylmethyl]-amino}-propan-2-ol

HRID 1634787Notes

Reaction equation

HRID 1634787 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:6][C:7]3[C:12]([C:13]=2[C:14]=1[O:15][CH2:16][C@@H:17]1[CH2:19][O:18]1)=[CH:11][CH:10]=[CH:9][CH:8]=3.NCC1CCN([C:28]2[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:29]=2[S:36]([NH2:39])(=[O:38])=[O:37])CC1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:6][C:7]3[C:12]([C:13]=2[C:14]=1[O:15][CH2:16][C@@H:17]([OH:18])[CH2:19][NH:6][CH2:5][CH:13]1[CH2:14][CH2:2][N:39]([S:36]([C:29]2[CH:28]=[CH:33][C:32]([O:34][CH3:35])=[CH:31][CH:30]=2)(=[O:37])=[O:38])[CH2:11][CH2:12]1)=[CH:11][CH:10]=[CH:9][CH:8]=3

Participants

3

Reactant 2

HCID 18678703HCID 18678703, compoundHCID 590329613-bromo-4-[(2S)-oxiranylmethoxy]-9H-carbazole

Product 1

HCID 10121505(2S)-1-(3-Bromo-9H-carbazol-4-yloxy)-3-{[1-(4-methoxy-benzenesulfonyl)-piperidin-4-ylmethyl]-amino}-propan-2-olYield 100.9%

Procedure

Prepared from 3-bromo-4-[(2S)-oxiranylmethoxy]-9H-carbazole (0.083 g, 0.26 mmol) and (4-aminomethyl-1-piperidinyl) 4-methoxybenzenesulfonamide (0.142 g, 0.5 mmol) according to procedure used for Example 2 to give 0.079 g of the title compound as a white solid.

Sources & evidence

ORD record
ord-4ca4c42f17df4810b59572e70797e24c
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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