HRID1634801

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](Oc1ccc(OC[C@@H]2CO2)cc1F)(c1ccccc1)c1ccccc1

HCID23381349

未命名化合物

结构：NCC1CCN(S(=O)(=O)c2ccc(NC(=O)NCc3cc(F)ccc3F)cc2)CC1.O=CO

HCID69999063

未命名化合物

PRODUCTS

生成物

结构：O=C(NCc1cc(F)ccc1F)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)COc3ccc(O)c(F)c3)CC2)cc1

HCID10304565

未命名化合物

收率 16%

PROCEDURE

实验过程

N-(4-{[4-(aminomethyl)-1-piperidinyl]sulfonyl}phenyl)-N′-(2,5-difluoro-benzyl)urea formate (0.433 g, 1.00 mmol) was reacted with t-butyl(diphenyl)silyl 2-fluoro-4-[(2S)oxiranylmethoxy]phenyl ether (0.422 g, 1.00 mmol) according to example 37 to give the title compound (0.1 g, 0.16 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6a9bab214f07407ca1b88dd387189080
来源数据集: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06506901B2
来源说明: uspto-grants-2003_01

反应 SMILES

C(O)=O.[NH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([S:12]([C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][CH2:25][C:26]3[CH:31]=[C:30]([F:32])[CH:29]=[CH:28][C:27]=3[F:33])=[O:23])=[CH:17][CH:16]=2)(=[O:14])=[O:13])[CH2:8][CH2:7]1.[F:34][C:35]1[CH:40]=[C:39]([O:41][CH2:42][C@@H:43]2[CH2:45][O:44]2)[CH:38]=[CH:37][C:36]=1[O:46][Si](C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>>[F:33][C:27]1[CH:28]=[CH:29][C:30]([F:32])=[CH:31][C:26]=1[CH2:25][NH:24][C:22]([NH:21][C:18]1[CH:17]=[CH:16][C:15]([S:12]([N:9]2[CH2:8][CH2:7][CH:6]([CH2:5][NH:4][CH2:45][C@H:43]([OH:44])[CH2:42][O:41][C:39]3[CH:38]=[CH:37][C:36]([OH:46])=[C:35]([F:34])[CH:40]=3)[CH2:11][CH2:10]2)(=[O:13])=[O:14])=[CH:20][CH:19]=1)=[O:23]