t-Butyl{2-fluoro-4-[(2s)oxiranylmethoxy]phenoxy}diphenylsilane → 1-(2,5-Difluoro-benzyl)-3-[4-(4-{[(2S)-3-(3-fluoro-4-hydroxy-phenoxy)-2-hydroxy-propylamino]-methyl}-piperidine-1-sulfonyl)-phenyl]-urea

Participants

Reaction Steps

N-(4-{[4-(aminomethyl)-1-piperidinyl]sulfonyl}phenyl)-N′-(2,5-difluoro-benzyl)urea formate (0.433 g, 1.00 mmol) was reacted with t-butyl(diphenyl)silyl 2-fluoro-4-[(2S)oxiranylmethoxy]phenyl ether (0.422 g, 1.00 mmol) according to example 37 to give the title compound (0.1 g, 0.16 mmol).

Provenance & Evidence