t-butyl(diphenyl)silyl 3-chloro-4-[(2S)oxiranylmethoxy]phenyl ether → 1-[4-(4-{[(2S)-3-(2-Chloro-4-hydroxy-phenoxy)-2-hydroxy-propylamino]-methyl}-piperidine-1-sulfonyl}-phenyl]-3-(2,5-difluoro-benzyl)-urea

Participants

Reaction Steps

N-(4-{[4-(aminomethyl)-1-piperidinyl]sulfonyl}phenyl)-N′-(2,5-difluorobenzyl)urea formate (0.827 g, 1.72 mmol) was reacted with t-butyl(diphenyl)silyl 3-chloro-4-[(2S)oxiranylmethoxy]phenyl ether (0.516 9,1.17 mmol) according to example 37 to give the title compound (0.15 g, 0.23 mmol).

Provenance & Evidence