HCID 18678495, compound → HCID 18678569, compound

HRID 1634804Notes

Reaction equation

HRID 1634804 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH2:9][CH2:10][NH:11][C:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([S:21]([N:24]2[CH2:29][CH2:28][CH:27]([CH:30](OC)[O:31]C)[CH2:26][CH2:25]2)(=[O:23])=[O:22])=[CH:17][CH:16]=1)=[O:13]>C(O)(C(F)(F)F)=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH2:9][CH2:10][NH:11][C:12]([NH:14][C:15]1[CH:16]=[CH:17][C:18]([S:21]([N:24]2[CH2:25][CH2:26][CH:27]([CH:30]=[O:31])[CH2:28][CH2:29]2)(=[O:22])=[O:23])=[CH:19][CH:20]=1)=[O:13]

Participants

3

Reactant 1

HCID 18678495HCID 18678495, compound

Product 1

HCID 18678569HCID 18678569, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 1-[2-(2,5-difluoro-phenyl)-ethyl]-3-[4-(4-dimethoxymethyl-piperidine-1-sulfonyl)-phenyl]-urea (0.170 g, 0.3 mmol) in 2 mL TFA was stirred for 15 minutes at ambient temperature. The excess TFA was removed in vacuo and the residue partitioned between ethyl acetate and water. The organic base was dried (Na2SO4) and the solvent evaporated to provide the title compound which was used directly in the next step.

Workup

  1. customThe excess TFA was removed in vacuo
  2. customthe residue partitioned between ethyl acetate and water
  3. dry with materialThe organic base was dried (Na2SO4)
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-bdd1d6e4205e4ba79baffc88d8448540
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

Loading…