HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluorobenzoic acid → Benzamide, 2,6-difluoro-N-methyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluorobenzoic acid | HCID 9796 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Product | Benzamide, 2,6-difluoro-N-methyl- | HCID 4106176 | — |
Reaction Steps
The title compound was prepared from 2,6-difluorobenzoic acid (10 g, 63.2 mmol), carbonyldiimidazole (10.26 g, 63.5 mmol), methylamine hydrochloride (4.27 g, 63.25 mmol) and diisopropylethyl amine according to the procedure used for example 84 (Step A) to give near quantitative yield of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06506901B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-87903239bff844dfb6b9479969497e88 |
| Source note | uspto-grants-2003_01 |