2,6-Difluorobenzoic acid → Benzamide, 2,6-difluoro-N-methyl-

HRID 1634808Notes

Reaction equation

[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4](O)=[O:5].[C:12](N1C=CN=C1)([N:14]1C=CN=C1)=O.Cl.CN.C(N(C(C)C)CC)(C)C>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([NH:14][CH3:12])=[O:5]

Participants

Reactant 4

HCID 97962,6-Difluorobenzoic acid

HCID 682631,1'-Carbonyldiimidazole

HCID 81531Diisopropylethylamine

HCID 6364545Methylamine hydrochloride

Product 1

HCID 4106176Benzamide, 2,6-difluoro-N-methyl-

Procedure

The title compound was prepared from 2,6-difluorobenzoic acid (10 g, 63.2 mmol), carbonyldiimidazole (10.26 g, 63.5 mmol), methylamine hydrochloride (4.27 g, 63.25 mmol) and diisopropylethyl amine according to the procedure used for example 84 (Step A) to give near quantitative yield of the title compound.

Sources & evidence

ORD record: ord-87903239bff844dfb6b9479969497e88
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06506901B2

Reaction notes

Loading…