Sodium Iodide → HCID 18678592, compound

HRID 1634814Notes

Reaction equation

[F:1][C:2]1[CH:35]=[CH:34][C:33]([F:36])=[CH:32][C:3]=1[CH2:4][N:5]([CH:29]([CH3:31])[CH3:30])[C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([N:18]2[CH2:23][CH2:22][CH:21]([CH:24](OC)[O:25]C)[CH2:20][CH2:19]2)(=[O:17])=[O:16])=[CH:11][CH:10]=1)=[O:7].[I-].[Na+].ClC([SiH3])(Cl)Cl>>[F:1][C:2]1[CH:35]=[CH:34][C:33]([F:36])=[CH:32][C:3]=1[CH2:4][N:5]([CH:29]([CH3:31])[CH3:30])[C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([N:18]2[CH2:19][CH2:20][CH:21]([CH:24]=[O:25])[CH2:22][CH2:23]2)(=[O:17])=[O:16])=[CH:11][CH:10]=1)=[O:7]

Participants

Reactant 3

HCID 5238Sodium Iodide

HCID 18678442HCID 18678442, compound

HCID 71317501CID 71317501

Product 1

HCID 18678592HCID 18678592, compound

Procedure

The title compound was prepared from 1-(2,5-difluoro-benzyl)-3-[4-(4-dimethoxymethyl-piperidine-1-sulfonyl)-phenyl]-1-isopropyl-urea (0.530 g, 0.001 mol), sodium iodide (0.188 g, 1.26 mmol), and trichloromethylsilane (0.118 mL, 1.0 mmol) according to the procedure used for example 84 (Step D) and used directly in the next step.

Sources & evidence

ORD record: ord-de207c4d74304dc7a2a7ae5496b1ea1e
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06506901B2

Reaction notes

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