Sodium Iodide → HCID 86758800, compound

HRID 1634821Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:38])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH:13][C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([S:23]([N:26]3[CH2:31][CH2:30][CH:29]([CH:32](OC)[O:33]C)[CH2:28][CH2:27]3)(=[O:25])=[O:24])=[CH:19][CH:18]=2)=[O:15])=[C:8]([F:37])[CH:7]=1.[I-].[Na+].ClC([SiH3])(Cl)Cl>>[CH3:1][O:2][C:3](=[O:38])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH:13][C:14]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([S:23]([N:26]3[CH2:31][CH2:30][CH:29]([CH:32]=[O:33])[CH2:28][CH2:27]3)(=[O:24])=[O:25])=[CH:21][CH:22]=2)=[O:15])=[C:8]([F:37])[CH:7]=1

Participants

Reactant 3

HCID 5238Sodium Iodide

HCID 70001350HCID 70001350, compound

HCID 71317501CID 71317501

Product 1

HCID 86758800HCID 86758800, compound

Procedure

The title compound was prepared from (4-{3-[4-(4-dimethoxymethyl-piperidine-1-sulfonyl)-phenyl]-ureidomethyl}-3-fluoro-phenoxy)-acetic acid methyl ester (0.274 g, 0.5 mmol), sodium iodide (0.185 g, 1.2 mmol), and trichloromethylsilane (0.118 mL, 1.0 mmol) according to the procedure used for example 84 (Step D) and used directly in the next step

Sources & evidence

ORD record: ord-22ce44038bf84ced897144c3d62b7909
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06506901B2

Reaction notes

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