Potassium Carbonate → HCID 18678511, compound

HRID 1634837Notes

Reaction equation

HRID 1634837 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH:17]1[CH2:22][CH2:21][CH:20]([CH2:23][OH:24])[CH2:19][CH2:18]1.C(=O)([O-])[O-].[K+].[K+]>>[N:11]1([S:8]([C:5]2[CH:6]=[CH:7][C:2]([N:17]3[CH2:22][CH2:21][CH:20]([CH2:23][OH:24])[CH2:19][CH2:18]3)=[CH:3][CH:4]=2)(=[O:10])=[O:9])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 4207714-PiperidinemethanolHCID 7553751-(4-Fluorophenylsulfonyl)piperidine

Product 1

HCID 18678511HCID 18678511, compound

Procedure

1-[(4-fluorophenyl)sulfonyl]piperidine (0.437 g, 1.8 mmol), 4-piperidinylmethanol (0.230 g, 2 mmol), and ;potassium carbonate (0.262 g, 2 mmol) were heated to 120° C. for 4 hours. The reaction was cooled, and partitioned between ethyl acetate and water. The organic layer was washed with aqueous HCl, and brine. It was dried with sodium sulfate, filtered, and removal of the solvent gave 0.040 g (0.12 mmol).

Workup

  1. temperatureThe reaction was cooled
  2. custompartitioned between ethyl acetate and water
  3. washThe organic layer was washed with aqueous HCl, and brine
  4. dry with materialIt was dried with sodium sulfate
  5. filtrationfiltered
  6. customremoval of the solvent
  7. customgave 0.040 g (0.12 mmol)

Sources & evidence

ORD record
ord-12955ae32ca240e8b43b138a46646b49
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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