Trifluoroacetic acid → HCID 88097297, compound

HRID 1634839Notes

Reaction equation

HRID 1634839 reaction equation
[CH2:1]([O:8][C:9](=[O:42])[C@@H:10]([NH:22][C:23](=[O:41])[C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH2:35][CH2:34][CH:33]([CH:36](OC)[O:37]C)[CH2:32][CH2:31]2)=[CH:26][CH:25]=1)[CH2:11][C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([O:8][C:9](=[O:42])[C@@H:10]([NH:22][C:23](=[O:41])[C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH2:31][CH2:32][CH:33]([CH:36]=[O:37])[CH2:34][CH2:35]2)=[CH:26][CH:25]=1)[CH2:11][C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69998476HCID 69998476, compound

Product 1

HCID 88097297HCID 88097297, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (2S)-2-{[4-(4-(dimethoxymethyl)piperidin-1-yl)benzoyl]-amino}-butanedioic acid dibenzyl ester (0.21 g, 0.4 mmol) in methylene chloride (10 mL) containing trifluoroacetic acid (0.2 ml, 2.6 mmol) was stirred at ambient temperature for 1 hour. The reaction was concentrated in vacuo to give the product which was used directly in the next step.

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. customto give the product which

Sources & evidence

ORD record
ord-c403e52c3476449bbe694199aec4d1f2
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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