HRID1634859

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID807

Iodine

HCID66053

N,N-Dimethylethylenediamine

C4H12N2

结构：CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC=C4CC(OC(=O)Cl)CC[C@]4(C)C3CC[C@@]21C

HCID54236888

未命名化合物

PRODUCTS

生成物

结构：CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)NCCN(C)C)CC[C@]4(C)[C@H]3CC[C@]12C

HCID115234

Cholest-5-en-3-yl hydrogen [2-(dimethylamino)ethyl]carbonimidate

C32H56N2O2

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

2 次

PROCEDURE

实验过程

Compound XIV was synthesized by mixing a solution of cholesteryl chloroformate (0.5 mmol) in chloroform with a solution of N,N-dimethylethylenediamine (9.1 mmol) in chloroform in a dry ice-ethanol bath. The solvent and the unreacted amine were removed in vacuo. Compound XIV was purified by two successive recrystallizations in ethanol. (Yield, 65%) TLC (chloroform:methanol=65:35) showed a single spot (Rf=0.37) when developed with iodine. The product was characterized by proton NMR.

WORKUP

后处理

customThe solvent and the unreacted amine were removed in vacuo
customCompound XIV was purified by two successive recrystallizations in ethanol
custom(Yield, 65%) TLC (chloroform:methanol=65:35)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b94860fa3c504ad783551749e3a961c6
来源数据集: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06509032B1
来源说明: uspto-grants-2003_01

反应 SMILES

[CH3:1][C@@H:2]([C@@H:9]1[C@@:13]2([CH3:31])[CH2:14][CH2:15][CH:16]3[C@@:21]4([CH3:30])[CH2:22][CH2:23][CH:24]([O:26][C:27](Cl)=[O:28])[CH2:25][C:20]4=[CH:19][CH2:18][CH:17]3[CH:12]2[CH2:11][CH2:10]1)[CH2:3][CH2:4][CH2:5][CH:6]([CH3:8])[CH3:7].[CH3:32][N:33]([CH3:37])[CH2:34][CH2:35][NH2:36].II>C(Cl)(Cl)Cl>[CH3:1][C@@H:2]([C@@H:9]1[C@@:13]2([CH3:31])[CH2:14][CH2:15][C@@H:16]3[C@@:21]4([CH3:30])[CH2:22][CH2:23][C@H:24]([O:26][C:27]([NH:36][CH2:35][CH2:34][N:33]([CH3:37])[CH3:32])=[O:28])[CH2:25][C:20]4=[CH:19][CH2:18][C@H:17]3[C@@H:12]2[CH2:11][CH2:10]1)[CH2:3][CH2:4][CH2:5][CH:6]([CH3:8])[CH3:7]