HCID 69529373, compound → Ethyl 3-[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]propionate

HRID 1634896Notes

Reaction equation

HRID 1634896 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH:19]=[CH:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:16]=[CH:15][N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]>CO.[Pd]>[CH3:12][O:11][C:7]1[CH:6]=[C:5]([C:13]2[CH:18]=[C:17]([CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:16]=[CH:15][N:14]=2)[CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[O:9][CH3:10]

Participants

4

Reactant 1

HCID 69529373HCID 69529373, compound

Product 1

HCID 18674991Ethyl 3-[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]propionate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Ethyl 3-[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]propenoate (579 mg) was dissolved in methanol (20 mL), 10% palladium on carbon (60 mg) was added to the solution, and the mixture was stirred at room temperature for 6 hours under a hydrogen atmosphere. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure to obtain the title compound.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0d0e6ebaa2d04065920da8266718c08b
Source dataset
uspto-grants-2003_01
Patent number
US06509329B1

Reaction notes

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