反应详情

Ethyl 2-(3,4,5-trimethoxyphenylethynyl)pyridine-4-carboxylate (1.40 g) was suspended in methanol (100 mL), to the suspension lithium hydroxide hydrate (189 mg) was added, and the mixture was stirred at room temperature for 4 hours. The reaction mixture was concentrated under reduced pressure, water was added to the residue and the resultant mixture was neutralized with 1 M hydrochloric acid. After the reaction mixture was cooled with ice, crystals precipitated were collected by filtration to obtain the title compound as colorless crystals.

1. additionwas added
2. concentrationThe reaction mixture was concentrated under reduced pressure, water
3. additionwas added to the residue
4. temperatureAfter the reaction mixture was cooled with ice, crystals
5. customprecipitated
6. filtrationwere collected by filtration