反应详情

温度

-74 °C

2-(4-Chloro-3-methoxy-2-pyridinyl)-butyronitrile (2.78 g) is dissolved in diethyl ether (150 ml), the solution is cooled to −74° C. and DIBAL (29 ml 1.0M) is added over a 30 min period. The solution is allowed to stir at −74° C. for an hour then at 0° C. for another hour. The reaction is quenched by addition of 5% sulfuric acid (25 ml), keeping the temperature around 0° C. The phases are separated and the organic phase washed with a solution of sodium bicarbonate, dried and evaporated to afford the desired product.

1. waitat 0° C. for another hour
2. customThe reaction is quenched by addition of 5% sulfuric acid (25 ml)
3. customthe temperature around 0° C
4. customThe phases are separated
5. washthe organic phase washed with a solution of sodium bicarbonate
6. customdried
7. customevaporated