HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 18675887, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-[3-(Trifluoromethyl)phenyl]-4-piperidinol | HCID 75255 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 2-(Quinolin-6-yl)acetic acid | HCID 11788709 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 18675887 | HCID 18675887 | 949.1% |
Reaction Steps
A mixture of 2.8 g (0.015 mol) of 6-quinolylacetic acid, 4.2 g (0.0015 mol) of 4-hydroxy-4-(3-trifluoromethylphenyl)piperidine, 6.63 g (0.015 mol) of BOP and 5.3 ml of triethylamine in 60 ml of methylene chloride is stirred overnight. 100 ml of ethyl acetate are added and the mixture is washed with water and with 1N sodium hydroxide solution and dried over sodium sulphate, and the solvent is evaporated off. 5.9 g of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06509351B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-c0aea2ee3bd14add983d4cffccf7c106 |
| Source note | uspto-grants-2003_01 |