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HRID1635361

反应详情

EQUATION

反应方程式

HRID 1635361 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccccc2)cc1N
HCID11404065

1,1-Dimethylethyl N-[2-amino-4-(2-phenylethynyl)phenyl]carbamate

C19H20N2O2

结构：CC1(C)OC(=O)C=C(c2cccc(OC(F)(F)F)c2)O1
HCID22224728

未命名化合物

PRODUCTS

生成物

1
结构：O=C1CC(c2cccc(C(F)(F)F)c2)=Nc2ccc(C#Cc3ccccc3)cc2N1
HCID22224583

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Prepared from (2-amino-4-phenylethynyl-phenyl)-carbamic acid tert.-butyl ester (Example G2) and 2,2-dimethyl-6-(3-trifluoromethoxy-phenyl)-[1,3]dioxin-4-one (Example J8) according to the general procedure K. The obtained material was deprotected and cyclized by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a yellow solid (157 mg).