HRID1635368

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

HCID11736337

未命名化合物

结构：CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccccn2)cc1N

HCID69592755

Carbamic acid, [2-amino-4-(2-pyridinylethynyl)phenyl]-, 1,1-dimethylethyl ester

C18H19N3O2

PRODUCTS

生成物

结构：N#Cc1cccc(C2=Nc3ccc(C#Cc4ccccn4)cc3NC(=O)C2)c1

HCID22224608

未命名化合物

收率 85.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Prepared from (2-amino-4-pyridin-2-ylethynyl-phenyl)-carbamic acid tert.-butyl ester (Example G19) (124 mg, 0.4 mmol) and 3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile (Example J4) (147 mg, 0.48 mmol) according to the general procedure K. The obtained material (199 mg) was deprotected and cyclized by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a yellow solid (124 mg).