Trifluoroacetic acid → HCID 9844433, compound

HRID 1635408Notes

Reaction equation

HRID 1635408 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[CH3:21])=[CH:10][C:9]=1[NH:22][C:23](=[O:38])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([N:33]2[CH:37]=[CH:36][N:35]=[CH:34]2)[CH:28]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:20][C:17]1[CH:18]=[CH:19][C:14]([C:11]2[CH:12]=[CH:13][C:8]3[N:7]=[C:25]([C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([N:33]5[CH:37]=[CH:36][N:35]=[CH:34]5)[CH:28]=4)[CH2:24][C:23](=[O:38])[NH:22][C:9]=3[CH:10]=2)=[C:15]([CH3:21])[CH:16]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588084HCID 86588084, compound

Product 1

HCID 9844433HCID 9844433, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {4′-fluoro-3-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-2′-methyl-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K50) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a beige solid (82 mg).

Sources & evidence

ORD record
ord-77545597c0c34d4ab0a9e1a126099b12
Source dataset
uspto-grants-2003_01
Patent number
US06509328B1

Reaction notes

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