Trifluoroacetic acid → HCID 22224938, compound

HRID 1635452Notes

Reaction equation

HRID 1635452 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18]([F:20])[CH:17]=CC=2F)=[CH:10][C:9]=1[NH:22][C:23](=[O:35])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]#[N:34])[CH:28]=1)=O)(C)(C)C.[C:37](O)([C:39]([F:42])(F)F)=O>C(Cl)Cl>[F:42][C:39]1[CH:37]=[CH:17][C:18]([F:20])=[CH:19][C:14]=1[C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[C:25]([C:27]3[CH:28]=[C:29]([CH:30]=[CH:31][CH:32]=3)[C:33]#[N:34])[CH2:24][C:23](=[O:35])[NH:22][C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588077HCID 86588077, compound

Product 1

HCID 22224938HCID 22224938, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {3-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-2′,5′-difluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K92) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light yellow solid (49 mg).

Sources & evidence

ORD record
ord-47de3e2b7dde42ce8986ae00ffe32e7b
Source dataset
uspto-grants-2003_01
Patent number
US06509328B1

Reaction notes

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