Trifluoroacetic acid → HCID 22224567, compound

HRID 1635461Notes

Reaction equation

HRID 1635461 reaction equation
O[C:2]([CH3:26])([CH3:25])[C:3]#[C:4][C:5]1[CH:24]=[CH:23][C:8]2[N:9]=[C:10]([C:15]3[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=3)[C:18]#[N:19])[CH2:11][C:12](=[O:14])[NH:13][C:7]=2[CH:6]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:26][C:2](=[CH2:25])[C:3]#[C:4][C:5]1[CH:24]=[CH:23][C:8]2[N:9]=[C:10]([C:15]3[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=3)[C:18]#[N:19])[CH2:11][C:12](=[O:14])[NH:13][C:7]=2[CH:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22224765HCID 22224765, compound

Product 1

HCID 22224567HCID 22224567, compoundYield 67.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from 3-[7-(3-hydroxy-3-methyl-but-1-ynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrile (Example 134) (50 mg, 0.15 mmol) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a sand solid (33 mg).

Sources & evidence

ORD record
ord-e96a61f6def74441a72328d7e69d871b
Source dataset
uspto-grants-2003_01
Patent number
US06509328B1

Reaction notes

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