Trifluoroacetic acid → HCID 22224602, compound

HRID 1635463Notes

Reaction equation

HRID 1635463 reaction equation
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14]#[C:15][C:16]2[CH:35]=[CH:34][C:19]3[N:20]=[C:21]([C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([C:32]#[N:33])[CH:27]=4)[CH2:22][C:23](=[O:25])[NH:24][C:18]=3[CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:25]=[C:23]1[CH2:22][C:21]([C:26]2[CH:27]=[C:28]([CH:29]=[CH:30][CH:31]=2)[C:32]#[N:33])=[N:20][C:19]2[CH:34]=[CH:35][C:16]([C:15]#[C:14][C:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=3)=[CH:17][C:18]=2[NH:24]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69592788HCID 69592788, compound

Product 1

HCID 22224602HCID 22224602, compoundYield 104.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from 4-[2-(3-cyano-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-7-ylethynyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert.-butyl ester (Example 139) (573 mg, 1.13 mmol) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as an off-white solid (434 mg).

Sources & evidence

ORD record
ord-8aa25e640a5c4996950c44a3d9e00cfd
Source dataset
uspto-grants-2003_01
Patent number
US06509328B1

Reaction notes

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