反应详情

A mixture of 2-benzylamino-4-[1-(3-methylphenyl)-3-methyl-1H-pyrazol-5-yl]pyridine (Example 19; 1.03 g, 0.0029 mol) and palladium hydroxide (0.2 g)in acetic acid was hydrogenated under 60 psi at 40° C. for 9 hours. The mixture was cooled and filtered through a pad of Celite™. The filtrate was concentrated and purified by chromatography on silica gel (ethyl acetate/hexane, 1:1) to give 0.43 g of product as a white solid: mp: 124-125° C.; Anal. Calc'd. for C16H16N4: C, 72.70; H, 6.10; N, 21.20. Found: C, 72.41; H, 6.31; N, 20.63.

1. temperatureThe mixture was cooled
2. filtrationfiltered through a pad of Celite™
3. concentrationThe filtrate was concentrated
4. custompurified by chromatography on silica gel (ethyl acetate/hexane, 1:1)