反应详情

温度

10 °C

An ice-cold mixture of the above ester (2.0 g, 9.1 mmol) in 30 mL of dichloromethane was treated with nitronium tetrafluoroborate (2.5 g, 18.8 mmol). The resulting mixture was stirred at 10° C. for 2 h and then at ambient temperature for 4 h. The reaction mixture was quenched with water (20 mL) and the organic layer was evaporated under vacuum. The white solid precipitate was collected by filtration, washed with water and dried to give 2.2 g (92%) of 1-(4-methoxycarbonyl-2-nitrophenyl)pyrrolidin-2-one, mp 159-161° C. (chloroforn/ether).

1. waitat ambient temperature for 4 h
2. customThe reaction mixture was quenched with water (20 mL)
3. customthe organic layer was evaporated under vacuum
4. filtrationThe white solid precipitate was collected by filtration
5. washwashed with water
6. customdried