反应详情

A suspension of the above ester (0.08 g, 0.2 mmol) in 1 N sodium hydroxide (1.5 mL) and methanol (1 mL) was stirred at ambient tmperature for 12 h. Upon acidification of the reaction mixture with glacial acetic acid, a solid precipitated. The solid was collected by filtration and dried to give 0.07 g (90%) of the title compound, mp 227-229° C.

1. customUpon acidification of the reaction mixture with glacial acetic acid, a solid precipitated
2. filtrationThe solid was collected by filtration
3. customdried