1-[2-(4-Heptylamino)-4-methoxycarbonylphenyl]-5,5-bis-(hydroxymethyl)pyrrolidin-2-one → 1-[4-Carboxy-2-(4-heptylamino)phenyl]-5,5-bis-(hydroxymethyl)pyrrolidin-2-one

Participants

Reaction Steps

A suspension of the above ester (0.08 g, 0.2 mmol) in 1 N sodium hydroxide (1.5 mL) and methanol (1 mL) was stirred at ambient tmperature for 12 h. Upon acidification of the reaction mixture with glacial acetic acid, a solid precipitated. The solid was collected by filtration and dried to give 0.07 g (90%) of the title compound, mp 227-229° C.

Provenance & Evidence