Methyl iodide → HCID 12468339, compound

HRID 1635596Notes

Reaction equation

HRID 1635596 reaction equation
[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][C:13]([O:19][CH3:20])=[C:14]([O:17][CH3:18])[CH:15]=3)[CH2:10][CH2:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:21][I:22]>CC(C)=O>[I-:22].[CH3:21][N+:8]1[CH2:9][CH2:10][C:11]2[C:16](=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=2)[C:7]=1[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 622378HCID 622378, compound

Product 1

HCID 12468339HCID 12468339, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a stirred solution of 1-phenyl-6,7-dimethoxy-3,4-dihydroisoquinoline in acetone was added methyl iodide and the reaction mixture was stirred at room temperature for 16 hours. A pale yellow precipitate was formed. The by-products and unreacted methyl iodide were removed in vacuo to afford the desired compound in 93% yield.

Workup

  1. customA pale yellow precipitate was formed
  2. customThe by-products and unreacted methyl iodide were removed in vacuo

Sources & evidence

ORD record
ord-b1c7ba3e56924271bdd4be34b654d294
Source dataset
uspto-grants-2003_01
Patent number
US06509467B1

Reaction notes

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