Lithium Hydroxide → HCID 12096141, compound

HRID 1635651Notes

Reaction equation

HRID 1635651 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([N:10]3[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]3[C:16]([O:18]CC)=[O:17])=[N:7][C:6]=2[CH:21]=1.[OH-].[Li+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([N:10]3[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]3[C:16]([OH:18])=[O:17])=[N:7][C:6]=2[CH:21]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 12096142HCID 12096142, compound

Product 1

HCID 12096141HCID 12096141, compound

Procedure

The title compound was prepared by a similar method to Preparation 3 from ethyl (2S)-1-(5-fluoro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylate [see Preparation 19] and 1N aqueous lithium hydroxide to afford (2S)-1-(5-fluoro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid as a solid.

Sources & evidence

ORD record
ord-4d01197cbd5843ba9a162ee2ef77f3ae
Source dataset
uspto-grants-2003_01
Patent number
US06509464B1

Reaction notes

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