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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1635689Generated: October 31, 2026

Water → 2-Difluoromethoxy-6-fluorobenzamidoxime

https://huagongshe.com/reaction/1635689

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantSodium CarbonateHCID 10340—
ReactantHydroxyamine hydrochlorideHCID 443297—
Reactant2-(Difluoromethoxy)-6-fluorobenzonitrileHCID 23448361—
SolventEthanolHCID 702—
Product2-Difluoromethoxy-6-fluorobenzamidoximeHCID 54540634—

Reaction Conditions

Temperature75 °C

Reaction Steps

A mixture of 6.4 g of 2-difluoromethoxy-6-fluorobenzonitrile and 3.1 g of hydroxylamine hydrochloride, 2.6 g of sodium carbonate, 7 ml of water and 35 ml of ethanol was stirred for 20 hours at 75° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06509501B2
Source datasetuspto-grants-2003_01
ORD IDord-0c017263458b466f830a3cce753b8d84
Source noteuspto-grants-2003_01