Water → 2-Difluoromethoxy-6-fluorobenzamidoxime

HRID 1635689Notes

Reaction equation

HRID 1635689 reaction equation
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[C:5]=1[C:6]#[N:7].Cl.[NH2:15][OH:16].C(=O)([O-])[O-].[Na+].[Na+].O>C(O)C>[F:13][CH:2]([F:1])[O:3][C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[C:5]=1[C:6](=[N:15][OH:16])[NH2:7]

Participants

6

Reactant 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 234483612-(Difluoromethoxy)-6-fluorobenzonitrile

Product 1

HCID 545406342-Difluoromethoxy-6-fluorobenzamidoxime

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

A mixture of 6.4 g of 2-difluoromethoxy-6-fluorobenzonitrile and 3.1 g of hydroxylamine hydrochloride, 2.6 g of sodium carbonate, 7 ml of water and 35 ml of ethanol was stirred for 20 hours at 75° C.

Sources & evidence

ORD record
ord-0c017263458b466f830a3cce753b8d84
Source dataset
uspto-grants-2003_01
Patent number
US06509501B2

Reaction notes

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