Triethylamine → HCID 17071139, compound

HRID 1635799Notes

Reaction equation

HRID 1635799 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH2:6].[CH3:10][C:11]([CH3:16])([CH3:15])[C:12](Cl)=[O:13].CCN(CC)CC>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH:6][C:12](=[O:13])[C:11]([CH3:16])([CH3:15])[CH3:10]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62493Pivaloyl chlorideHCID 77802Benzenemethanamine, 3-chloro-

Product 1

HCID 17071139HCID 17071139, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-chlorobenzylamine (3.54 g, 25 mmol) was added dropwise to trimethylacetyl chloride (2.65 ml, 21.5 mmol) and Et3N (3.5 ml, 25 mmol) in DCM (25 ml). After two hours, the reaction mixture was washed with 1N HCl and the organic layer collected and dried over MgSO4. N-3-chlorobenzyltrimethylacetamide was precipitated from DCM/hexane as a white solid, 3.95 g,

Workup

  1. washthe reaction mixture was washed with 1N HCl
  2. customthe organic layer collected
  3. dry with materialdried over MgSO4
  4. customN-3-chlorobenzyltrimethylacetamide was precipitated from DCM/hexane as a white solid, 3.95 g

Sources & evidence

ORD record
ord-12c52c5bfc3b4f52be573b9c2e41c74d
Source dataset
uspto-grants-2003_01
Patent number
US06511980B2

Reaction notes

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