HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 2-Methoxy-4-(3-methyl-pyrazol-1-yl)-benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 2-Methoxy4-(3-methyl-pyrazol-1-yl)-benzoic acid, methyl ester | HCID 54421105 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Methoxy-4-(3-methyl-pyrazol-1-yl)-benzoic Acid | HCID 22605461 | — |
Reaction Steps
A solution of 2-methoxy-4-(3-methyl-pyrazol-1-yl)-benzoic acid methyl ester (0.5 g) from Example 105 in tetrahydrofuran (2.5 ml) was treated with 1 N lithium hydroxide (2.13 ml) at room temperature. After 14 hours the solvent was removed in vacuo and the title compound precipitated by the addition at 0° C. of 1N hydrochloric acid. After drying under vacuum 0.42 g of the title compound was obtained as a solid. MS, m/z: 232 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06511974B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-bcaf02d28ec04c93a83aa3ecfd81e942 |
| Source note | uspto-grants-2003_01 |