反应详情

温度

100 °C

A mixture of the product from part 3 (12.5 g) in 50 ml of POCl3 is stirred at 100° C. for about two hours then cooled and concentrated under vacuum. The residue is dissolved in 300 ml of CHCl3, and the resulting solution is washed with aqueous NaHCO3 and water, dried over Na2SO4, filtered and then concentrated to give the title compound, m.p. 53-55° C.

1. temperaturethen cooled
2. concentrationconcentrated under vacuum
3. dissolutionThe residue is dissolved in 300 ml of CHCl3
4. washthe resulting solution is washed with aqueous NaHCO3 and water
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated