2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({5-[(1,1-dioxidothiomorpholin-4-yl)methyl]-6-fluoropyridin-2-yl}amino)thiophene-3-carboxamide

HRID 163592Notes

Reaction equation

HRID 163592 reaction equation
[Cl:22][c:23]1[cH:24][cH:25][c:26]([CH2:30][N:31]2[CH2:32][CH2:33][S:34](=[O:37])(=[O:38])[CH2:35][CH2:36]2)[c:27]([F:29])[n:28]1.[NH2:1][c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9]>>[NH:1]([c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9])[c:23]1[cH:24][cH:25][c:26]([CH2:30][N:31]2[CH2:32][CH2:33][S:34](=[O:37])(=[O:38])[CH2:35][CH2:36]2)[c:27]([F:29])[n:28]1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595257164-[(6-Chloro-2-fluoropyridin-3-yl)methyl]thiomorpholine 1,1-dioxide

Product 1

HCID 686706735-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({5-[(1,1-dioxidothiomorpholin-4-yl)methyl]-6-fluoropyridin-2-yl}amino)thiophene-3-carboxamide

Sources & evidence

ORD record
ord-97a3508536e748339cf1aaf0d3db8771
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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